Andrew was probably the best-educated and shrewdest of the original Huston siblings. He was a county clerk in Ross County in 1816 and later played a prominent role in the city of Circleville in Pickaway County. He and brother Thomas were part of the committee responsible for the "circling of the square" in Circleville. Andrew owned a lot of land and amassed a fortune. He was married, probably about 1836 when he was in his forties, to Cynthia Renick, daughter of a prominent family in Pickaway who were also Andrew's business partners. They had one son, Renick Huston, born 1838. Cynthia apparently died before 1850, as she doesn't appear in the census that year, and twelve-year-old Renick is living with another family. Cynthia isn't mentioned in Andrew's will of 1854, written just before he died, in which he appoints Jonathan Renick as young Renick's guardian.

Renick Huston enlisted in Company E, 43rd Infantry Regiment Ohio on Dec. 20, 1861 when he was 24. He was promoted to Full 2nd Lieutenant on May 17, 1862, and then to Full 1st Lieutenant on Aug 12, 1862. He resigned a year later on Jun 22 1863, probably due to illness or injury, as he died 6 months later. His estate later became the focus of a lawsuit, Smith v. Ayer, which involved the squandering of about $80,000 (an immense sum in those days) by one Thomas Renick.